過去の記録

2019年10月17日(木)

FMSPレクチャーズ

13:00-15:05   数理科学研究科棟(駒場) 002号室

Chung-jun Tsai 氏 (National Taiwan University)
Topic on minimal submanifolds (4/6) (ENGLISH)
[ 講演概要 ]
The main theme of these lectures will be theory about minimal submanifolds, which are higher dimensional generalizations of geodesics. A naive motivation is that one tries to understand the geometry from its special submanifolds (minimal, etc.).

For minimal submanifolds, the equations are no longer ODEs, but elliptic PDEs. This increases the difficulties. The study are very good examples for the application of methods from PDEs and calculus of variations. We will try to explain some important results in this theory, which stimulate many of the researches today.

Here are some specific materials we plan to cover: Simon’s work based on the second variational formula, Sacks - Uhlenback theorem on the existence of minimal 2-spheres, the theory of stable minimal hypersurfaces by Schoen-Simon-Yau.
[ 講演参考URL ]
http://fmsp.ms.u-tokyo.ac.jp/FMSPLectures_Tsai.pdf

情報数学セミナー

16:50-18:35   数理科学研究科棟(駒場) 122号室
AIと量子計算（暗号理論を含む）を主題とする

CASE+AI時代の５Gデータセンター (Japanese)
[ 講演概要 ]

イバーセキュリティの重要性」の３つがあげられる。本連携講座では、このトレ
ンドに沿って、「AIと量子計算」を主テーマとし暗号理論の最前線にも触れなが
ら議論を深めていきたいと考えている。今回は、その第1回として、情報社会に
おいて情報収集拠点と共に情報発信拠点であるデータセンターの最新事情につい
て述べる。ここで起きている産業のデジタル化の中で、自動車産業が「CASE」
（Connected、Autonomous、Sharing & Services、Electrification）へと大転換
していることを取り上げデータセンターとの関係について述べることとする。

数理人口学・数理生物学セミナー

14:00-16:00   数理科学研究科棟(駒場) 052号室
Merlin C. Koehnke 氏 (Institute of Environmental Systems Research, School of Mathematics/Computer Science, Osnabrueck University) 14:00-15:00
Complex spatiotemporal dynamics in a simple predator-prey model (ENGLISH)
[ 講演概要 ]
A simple reaction-diffusion predator-prey model with Holling type IV functional response
and logistic growth in the prey is considered. The functional response can be interpreted as
a group defense mechanism, i.e., the predation rate decreases with resource density when the
prey density is high enough [1]. Such a mechanism has been described in diverse biological
interactions [2,3]. For instance, high densities of filamentous algae can decrease filtering
rates of filter feeders [4].
The model will be described and linked to plankton dynamics. Nonspatial considerations reveal that the zooplankton may go extinct or coexistence (stationary or oscillatory) between
zoo- and phytoplankton may emerge depending on the choice of parameters. However,
including space, the dynamics are more complex. In particular, spatiotemporal irregular
oscillations can rescue the predator from extinction. These oscillations can be characterized
as spatiotemporal chaos. The results provide a simple mechanism not only for the emergence
of inhomogeneous plankton distributions [5] but also for the occurrence of chaos in plankton communities [6]. Possible underlying mechanisms for this phenomenon will be discussed.
References
[1] Freedman, H. I., Wolkowicz, G. S. (1986). Predator-prey systems with group defence: the
paradox of enrichment revisited. Bulletin of Mathematical Biology, 48(5-6), 493–508.
[2] Tener, J. S.. Muskoxen in Canada: a biological and taxonomic review. Vol. 2. Dept. of Northern
Affairs and National Resources, Canadian Wildlife Service, 1965.
[3] Holmes, J. C. (1972). Modification of intermediate host behaviour by parasites. Behavioural
aspects of parasite transmission.
[4] Davidowicz, P., Gliwicz, Z. M., Gulati, R. D. (1988). Can Daphnia prevent a blue-green algal
bloom in hypertrophic lakes? A laboratory test. Limnologica. Jena, 19(1), 21–26.
[5] Abbott, M., 1993. Phytoplankton patchiness: ecological implicationsand observation methods.
In: Levin, S.A., Powell, T.M., Steele, J.H.(Eds.), Patch Dynamics. Lecture Notes in Biomathematics, vol. 96. Springer-Verlag, Berlin, pp. 37–49.
[6] Beninc`a, E. et al. (2008). Chaos in a long-term experiment with a plankton community. Nature,
451(7180), 822.
Horst Malchow 氏 (Institute of Environmental Systems Research, School of Mathematics/Computer Science, Osnabrueck University) 15:00-16:00
Functional response of competing populations to environmental variability (ENGLISH)
[ 講演概要 ]
The possible control of competitive invasion by infection of the invader and multiplicative
noise is studied. The basic model is the Lotka-Volterra competition system with emergent
carrying capacities. Several stationary solutions of the non-infected and infected system are
identi ed as well as parameter ranges of bistability. The latter are used for the numerical
study of di usive invasion phenomena. The Fickian di usivities, the infection but in particular the white and colored multiplicative noise are the control parameters. It is shown
that not only competition, possible infection and mobilities are important drivers of the
invasive dynamics but also the noise and especially its color and the functional response of
populations to the emergence of noise.
The variability of the environment can additionally be modelled by applying Fokker-Planck
instead of Fickian di usion. An interesting feature of Fokker-Planck di usion is that for spatially varying di usion coecients the stationary solution is not a homogeneous distribution.
Instead, the densities accumulate in regions of low di usivity and tend to lower levels for
areas of high di usivity. Thus, the stationary distribution of the Fokker-Planck di usion can
be interpreted as a re
ection of di erent levels of habitat quality [1-5]. The latter recalls the
seminal papers on environmental density, cf. [6-7]. Appropriate examples will be presented.
References
[1] Bengfort, M., Malchow, H., Hilker, F.M. (2016). The Fokker-Planck law of diffusion and
pattern formation in heterogeneous media. Journal of Mathematical Biology 73(3), 683-704.
[2] Siekmann, I., Malchow, H. (2016). Fighting enemies and noise: Competition of residents
and invaders in a stochastically fluctuating environment. Mathematical Modelling of Natural
Phenomena 11(5), 120-140.
[3] Siekmann, I., Bengfort, M., Malchow, H. (2017). Coexistence of competitors mediated by
nonlinear noise. European Physical Journal Special Topics 226(9), 2157-2170.
[4] Kohnke, M.C., Malchow, H. (2017). Impact of parameter variability and environmental noise
on the Klausmeier model of vegetation pattern formation. Mathematics 5, 69 (19 pages).
[5] Bengfort, M., Siekmann, I., Malchow, H. (2018). Invasive competition with Fokker-Planck
di usion and noise. Ecological Complexity 34, 134-13.
[6] Morisita, M. (1971). Measuring of habitat value by the \environmental density" method. In:
Spatial patterns and statistical distributions (Patil, C.D., Pielou, E.C., Waters, W.E., eds.),
Statistical Ecology, vol. 1, pp. 379-401. Pennsylvania State University Press, University Park.
[7] N. Shigesada, N., Kawasaki, K., Teramoto, E. (1979). Spatial segregation of interacting species.
Journal of Theoretical Biology 79, 83-99.

2019年10月16日(水)

作用素環セミナー

16:45-18:15   数理科学研究科棟(駒場) 126号室

Developments in conformal bootstrap analysis

代数学コロキウム

17:30-18:30   数理科学研究科棟(駒場) 056号室
Liang Xiao 氏 (BICMR, Peking University)
On slopes of modular forms (ENGLISH)
[ 講演概要 ]
In this talk, I will survey some recent progress towards understanding the slopes of modular forms, with or without level structures. This has direct application to the conjecture of Breuil-Buzzard-Emerton on the slopes of Kisin's crystabelline deformation spaces. In particular, we obtain certain refined version of the spectral halo conjecture, where we may identify explicitly the slopes at the boundary when given a reducible non-split generic residual local Galois representation. This is a joint work in progress with Ruochuan Liu, Nha Truong, and Bin Zhao.

（本講演は「東京北京パリ数論幾何セミナー」として，インターネットによる東大数理，Morningside Center of Mathematics と IHES の双方向同時中継で行います．今回は北京からの中継です．）

代数幾何学セミナー

15:30-17:00   数理科学研究科棟(駒場) 122号室

Multidimensional continued fraction for Gorenstein cyclic quotient singularity
[ 講演概要 ]
Let G be a finite cyclic subgroup of GL(n,C). Then Cn/G is a cyclic quotient singularity. In the case n = 2, Cn/G possess the unique minimal resolution, and it is obtained by Hirzubruch-Jung continued fraction. In this talk, we show a sufficient condition of existence of crepant desingularization for Gorenstein abelian quotient singularities in all dimensions by using Ashikaga’s continuous fractions. Moreover, as a corollary, we prove that all three dimensional Gorenstein abelian quotient singularities possess a crepant desingularization.

2019年10月15日(火)

トポロジー火曜セミナー

17:00-18:30   数理科学研究科棟(駒場) 056号室
Tea: Common Room 16:30-17:00
Gwénaël Massuyeau 氏 (Université de Bourgogne)
Generalized Dehn twists on surfaces and surgeries in 3-manifolds (ENGLISH)
[ 講演概要 ]
(Joint work with Yusuke Kuno.) Given an oriented surface S and a simple closed curve C in S, the "Dehn twist" along C is the homeomorphism of S defined by "twisting" S around C by a full twist. If the curve C is not simple, this transformation of S does not make sense anymore, but one can consider two possible generalizations: one possibility is to use the homotopy intersection form of S to "simulate" the action of a Dehn twist on the (Malcev completion of) the fundamental group of S; another possibility is to view C as a curve on the top boundary of the cylinder S×[0,1], to push it arbitrarily into the interior so as to obtain, by surgery along the resulting knot, a new 3-manifold. In this talk, we will relate two those possible generalizations of a Dehn twist and we will give explicit formulas using a "symplectic expansion" of the fundamental group of S.

2019年10月10日(木)

情報数学セミナー

16:50-18:35   数理科学研究科棟(駒場) 122号室
AIと量子計算（暗号理論を含む）を主題とする

[ 講演概要 ]

FMSPレクチャーズ

13:00-15:05   数理科学研究科棟(駒場) 002号室

Chung-jun Tsai 氏 (National Taiwan University)
Topic on minimal submanifolds (3/6) (ENGLISH)
[ 講演概要 ]
The main theme of these lectures will be theory about minimal submanifolds, which are higher dimensional generalizations of geodesics. A naive motivation is that one tries to understand the geometry from its special submanifolds (minimal, etc.).

For minimal submanifolds, the equations are no longer ODEs, but elliptic PDEs. This increases the difficulties. The study are very good examples for the application of methods from PDEs and calculus of variations. We will try to explain some important results in this theory, which stimulate many of the researches today.

Here are some specific materials we plan to cover: Simon’s work based on the second variational formula, Sacks - Uhlenback theorem on the existence of minimal 2-spheres, the theory of stable minimal hypersurfaces by Schoen-Simon-Yau.
[ 講演参考URL ]
http://fmsp.ms.u-tokyo.ac.jp/FMSPLectures_Tsai.pdf

離散数理モデリングセミナー

17:00-18:00   数理科学研究科棟(駒場) 056号室
Boris Konopelchenko 氏 (INFN, sezione di Lecce, Lecce, Italy)
Universal parabolic regularization of gradient catastrophes for the Burgers-Hopf equation and singularities of the plane into plane mappings of parabolic type (English)
[ 講演概要 ]
Two intimately connected topics, namely, regularization of gradient catastrophes of all orders for the Burgers-Hopf equation via the Jordan chain and the singularities of the plane into plane mappings
associated with two-component hydrodynamic type systems of parabolic type are discussed.
It is shown that the regularization of all gradient catastrophes (generic and higher orders) for the Burgers-Hopf equation is achieved by the step by step embedding of the Burgers-Hopf equation into multi-component parabolic systems of quasilinear PDEs with the most degenerate Jordan blocks. Infinite parabolic Jordan chain provides us with the complete regularization. This chain contains Burgers and KdV equations as particular reductions.
It is demonstrated that the singularities of the plane into planes mappings associated with the two-component system of quasilinear PDEs of parabolic type are quite different from those in hyperbolic and elliptic cases. Impediments arising in the application of the original Whitney's approach to such case are discussed. It is shown that flex is the lowest singularity while higher singularities are given by ( k+1,k+2) curves which are of cusp type for k=2n+1, n=1,2,...,. Regularization of these singularities is discussed.

Presentation is based on two publications:

1. B. Konopelchenko and G. Ortenzi, Parabolic regularization of the gradient catastrophes for the Burgers-Hopf equation and Jordan chain, J. Phys. A: Math. Theor., 51 (2018) 275201.

2. B.G. Konopelchenko and G. Ortenzi, On the plane into plane mappings of hydrodynamic type. Parabolic case. Rev. Math. Phys.,32 (2020) 2020006. Online access. arXiv:1904.00901.

2019年10月09日(水)

作用素環セミナー

16:45-18:15   数理科学研究科棟(駒場) 126号室

Relative K-homology group of $C^*$-algebras and almost flat vector bundle on manifolds with boundary

代数学コロキウム

17:00-18:00   数理科学研究科棟(駒場) 056号室
Yuanqing Cai 氏 (京都大学)
Twisted doubling integrals for classical groups (ENGLISH)
[ 講演概要 ]
In the 1980s, Piatetski-Shapiro and Rallis discovered a family of Rankin-Selberg integrals for the classical groups that did not rely on Whittaker models. This is the so-called doubling method. It grew out of Rallis' work on the inner products of theta lifts -- the Rallis inner product formula.
In this talk, we present a family of Rankin-Selberg integrals (the twisted doubling method, in joint work with Friedberg, Ginzburg, and Kaplan) for the tensor product L-function of a pair of automorphic cuspidal representations, one of a classical group, the other of a general linear group. This can be viewed as a generalization of the doubling integrals of Piatetski-Shapiro and Rallis. Time permitting, we will discuss the twisted doubling integrals for Brylinski-Deligne covers of classical groups.

2019年10月08日(火)

トポロジー火曜セミナー

17:30-18:30   数理科学研究科棟(駒場) 056号室
Tea: Common Room 17:00-17:30

いかにして双曲的力学系を群作用に拡張するか？ (JAPANESE)
[ 講演概要 ]

ナイーブには困難です．例えば $Z^2$ の作用を考えましょう（つまり可換な 2 パラメータ作用）・簡単にわかるのは，有限次元のコンパクト多様体に $Z^2$ が可微分に作用するとき，その $Z^2$ 作用としてのエントロピーはゼロになります．つまり，通常の有限次元の状況には，豊かな $Z^2$ 作用は存在しません．言い換えると，十分に豊かな群作用を得るためには無限次元の世界に行かざるを得ません．しかし，無限次元の世界でどのような構造を見出せばよいのでしょうか？

この講演では，このような方向性にアプローチする際に，平均次元と呼ばれる量が大きな役割を果たす可能性を説明します．特に，次のような原理についてお話します：

$Z^k$（可換な $k$ パラメータ群）が空間 $X$ に何らかの「双曲性」を持って作用するとき，$Z^k$ のランク $k-1$ の部分群 $G$ の部分作用に対する平均次元が制御できる．

この講演はTom Meyerovitch，篠田万穂との共同研究に基づきます．

2019年10月07日(月)

複素解析幾何セミナー

10:30-12:00   数理科学研究科棟(駒場) 128号室

Cohomology of vector bundles and non-pluriharmonic loci (Japanese)
[ 講演概要 ]
We study cohomology groups of vector bundles on neighborhoods of a non-pluriharmonic locus in Stein manifolds and in projective manifolds. By using our results, we show variants of the Lefschetz hyperplane theorem. We especially study the examples of non-pluriharmonic loci in smooth toric varieties. I would like to explain the relation of non-pluriharmonic loci and polytopes.

2019年10月04日(金)

離散数理モデリングセミナー

17:30-18:30   数理科学研究科棟(駒場) 118号室
Anton Dzhamay 氏 (University of Northern Colorado)
Recurrence coefficients for discrete orthogonal polynomials with hypergeometric weight and discrete Painlevé equations (English)
[ 講演概要 ]
Over the last decade it became clear that the role of discrete Painlevé equations in applications has been steadily growing. Thus, the question of recognizing a certain non-autonomous recurrence as a discrete Painlevé equation and understanding its position in Sakai’s classification scheme, recognizing whether it is equivalent to some known (model) example, and especially finding an explicit change of coordinates transforming it to such example, becomes one of the central ones. Fortunately, Sakai’s geometric theory provides an almost algorithmic procedure of answering this question.
In this work we illustrate this procedure by studying an example coming from the theory of discrete orthogonal polynomials. There are many connections between orthogonal polynomials and Painlevé equations, both differential and discrete. In particular, often the coefficients of three-term recurrence relations for orthogonal polynomials can be expressed in terms of solutions of some discrete Painlevé equation. In this work we study orthogonal polynomials with general hypergeometric weight and show that their recurrence coefficients satisfy, after some change of variables, the standard discrete Painlevé-V equation. We also provide an explicit change of variables transforming this equation to the standard form.
This is joint work with Galina Filipuk (University of Warsaw, Poland) and Alexander Stokes (University College, London, UK)

2019年10月03日(木)

FMSPレクチャーズ

13:00-15:05   数理科学研究科棟(駒場) 002号室

Chung-jun Tsai 氏 (National Taiwan University)
Topic on minimal submanifolds (2/6) (ENGLISH)
[ 講演概要 ]
The main theme of these lectures will be theory about minimal submanifolds, which are higher dimensional generalizations of geodesics. A naive motivation is that one tries to understand the geometry from its special submanifolds (minimal, etc.).

For minimal submanifolds, the equations are no longer ODEs, but elliptic PDEs. This increases the difficulties. The study are very good examples for the application of methods from PDEs and calculus of variations. We will try to explain some important results in this theory, which stimulate many of the researches today.

Here are some specific materials we plan to cover: Simon’s work based on the second variational formula, Sacks - Uhlenback theorem on the existence of minimal 2-spheres, the theory of stable minimal hypersurfaces by Schoen-Simon-Yau.
[ 講演参考URL ]
http://fmsp.ms.u-tokyo.ac.jp/FMSPLectures_Tsai.pdf

2019年10月02日(水)

作用素環セミナー

16:45-18:15   数理科学研究科棟(駒場) 126号室
David E. Evans 氏 (Cardiff University)
Subfactors, K-theory and Equivariant Higher Twists (English)

2019年10月01日(火)

トポロジー火曜セミナー

17:00-18:30   数理科学研究科棟(駒場) 056号室
Tea: Common Room 16:30-17:00

Quantized SL(2) representations of knot groups (JAPANESE)
[ 講演概要 ]
Let K be a knot and G be a group. The representation space of K for the group G means the space of homomorphisms from the knot group to G and is defined by using the group ring C[G], where C[G] is the ring of functions on G and has a commutative Hopf algebra structure. This construction can be generalized to any commutative Hopf algebras.

In this talk, we extend this construction to any braided Hopf algebras with braided commutativity. A typical example is BSL(2), which is the braided SL(2) introduced by S. Majid. Applying the above construction to BSL(2), we get the space of BSL(2) representations, which provides a quantization of SL(2) representations of a knot. This is joint work with Roloand van der Veen.

2019年09月30日(月)

複素解析幾何セミナー

10:30-12:00   数理科学研究科棟(駒場) 128号室

Rigidity of the directional moduli on pseudoconvex domains fibered by open Riemann surfaces
[ 講演概要 ]
G. Schmieder-M. Shiba observed conformal embeddings of a fixed open Riemann surface of positive finite genus into closed Riemann surfaces of the same genus, and they showed the range of each diagonal element of the period matrices. Now we shall consider a smooth deformation of open Riemann surfaces with a complex parameter. In this talk, we show the rigidity of directional moduli induced by elements of the period matrices on pseudoconvex domains fibered by open Riemann surfaces of the same topological type.

2019年09月26日(木)

FMSPレクチャーズ

13:00-15:05   数理科学研究科棟(駒場) 002号室

Chung-jun Tsai 氏 (National Taiwan University)
Topic on minimal submanifolds (1/6) (ENGLISH)
[ 講演概要 ]
The main theme of these lectures will be theory about minimal submanifolds, which are higher dimensional generalizations of geodesics. A naive motivation is that one tries to understand the geometry from its special submanifolds (minimal, etc.).

For minimal submanifolds, the equations are no longer ODEs, but elliptic PDEs. This increases the difficulties. The study are very good examples for the application of methods from PDEs and calculus of variations. We will try to explain some important results in this theory, which stimulate many of the researches today.

Here are some specific materials we plan to cover: Simon’s work based on the second variational formula, Sacks - Uhlenback theorem on the existence of minimal 2-spheres, the theory of stable minimal hypersurfaces by Schoen-Simon-Yau.
[ 講演参考URL ]
http://fmsp.ms.u-tokyo.ac.jp/FMSPLectures_Tsai.pdf

2019年09月25日(水)

数値解析セミナー

16:30-18:00   数理科学研究科棟(駒場) 056号室

Keller-Segel方程式の保存型の有限体積法について (Japanese)
[ 講演概要 ]
Keller-Segel方程式に対して，有限体積法の保存型の非線形的なスキームを提案した．まず離散解の存在性を示し，半群理論を用いて誤差評価を行った．特に，1次収束を示すために必要な離散解の事前評価を示した．さらに，自明な定常解に収束する場合に適用する離散Laypunov汎関数を定義し，Laypunov不等式を証明した．最後に爆発解について，離散Laypunov汎関数やスキームの提案について少し話したい．

2019年08月20日(火)

博士論文発表会

13:45-15:00   数理科学研究科棟(駒場) 122号室

Brane coproducts and their applications
(ブレーン余積とその応用)
(JAPANESE)

2019年08月19日(月)

数値解析セミナー

13:00-17:00   数理科学研究科棟(駒場) 122号室
"Mini Workshop on Recent Developments in Discontinuous Galerkin Methods"として開催
Eric Chung 氏 (The Chinese University of Hong Kong) 13:00-14:00
Staggered hybridisation for discontinuous Galerkin methods (英語)
[ 講演概要 ]
In this talk, we present a new staggered hybridization technique for discontinuous Galerkin methods to discretize linear elastodynamic equations and nonlinear Stokes equations. The idea of hybridization is used extensively in many discontinuous Galerkin methods, but the idea of staggered hybridization is new. Our new approach offers several advantages, namely energy conservation, high-order optimal convergence, preservation of symmetry for the stress tensor, block diagonal mass matrices as well as low dispersion error. The key idea is to use two staggered hybrid variables to enforce the continuity of the velocity and the continuity of the normal component of the stress tensor on a staggered mesh. We prove the stability and the convergence of the proposed scheme in both the semi-discrete and the fully-discrete settings. Numerical results confirm the optimal rate of convergence and show that the method has a superconvergent property for dispersion.
Feifei Jing 氏 (Northwestern Polytechnical University) 14:30-15:30
DG and HDG methods for the variational inequality problems (英語)
[ 講演概要 ]
There exist many numerical methods for solving the fluid dynamics equations, the main difference between them lies in the partitions of geometric domain and the discrete forms of governing equations. Due to the discontinuous piecewise polynomial subspaces, DG and HDG methods can be easily implemented on highly unstructured meshes, e.g. general polygonal mesh, and volume integrals could be calculated on physical elements, without reference elements and mappings between physical and reference elements. In this talk, DG and HDG methods employed to a class of variational inequality problems arising in hydrodynamics are studied. Some theoretical results will be shown, as well as the implementations of these methods are also put into practice.

A new HDG method using a hybridized flux (英語)
[ 講演概要 ]
We propose a new hybridizable discontinuous Galerkin (HDG) method for steady-state diffusion problems. In our method, both the trace and flux of the exact solution are hybridized. The Lehrenfeld-Schöberl stabilization is implicitly included in the method, so that the orders of convergence in all variables are optimal without postprocessing and computation of any projection. Numerical results are present to show the validation of our method.

Numerical approximation of the Stokes–Darcy problem using discontinuous linear elements (英語)
[ 講演概要 ]
We consider the Stokes–Darcy interface problem supplemented with the Beavers– Joseph–Saffman condition on the interface separating two domains. This condition allows for discontinuity in the tangential velocities and in the pressures along the interface. To effectively express it, we propose to use discontinuous linear finite elements to approximate all of the velocities/pressures in the Stokes/Darcy regions. The continuity of velocity in the normal direction is weakly enforced by adopting either the penalty method or Nitsche’s method. We present stability and error estimates for the proposed scheme, taking into account the situation where a curved interface is approximated by a polygonal curve or polyhedral surface.

2019年08月01日(木)

数理人口学・数理生物学セミナー

15:00-16:00   数理科学研究科棟(駒場) 118号室
Yueping Dong 氏 (Central China Normal University)
Mathematical study of the inhibitory role of regulatory T cells in tumor immune response
[ 講演概要 ]
The immune system against tumor is a complex dynamical process showing a dual role. On the one hand, the immune system can activate some immune cells to kill tumor cells, such as cytotoxic T lymphocytes (CTLs) and natural killer cells (NKs), but on the other hand, more evidence shows that some immune cells can help tumor escape, such as regulatory T cells (Tregs). In this talk, we propose a tumor immune interaction model based on Tregs mediated tumor immune escape mechanism. When HTCs stimulation rate by the presence of identified tumor antigens below the critical value, the interior equilibrium P* is always stable in the region of existence. When HTCs stimulation rate higher than the critical value, the Inhibition rate of ECs by Tregs can destabilize P* and cause Hopf bifurcations and produce limit cycle. This model shows that Tregs might play a crucial role in triggering the immune escape of tumor cells. Furthermore, we introduce the adoptive cellular immunotherapy (ACI) and monoclonal immunotherapy as the treatment to boost the immune system to fight against tumors. The numerical results show that ACI can control more tumor cells, while monoclonal immunotherapy can delay the inhibitory effect of Tregs on effector cells (ECs). The results also show that the combination immunotherapy can control tumor cells and reduce the inhibitory effect of Tregs better than single immunotherapy.

2019年07月25日(木)

作用素環セミナー

16:45-18:15   数理科学研究科棟(駒場) 126号室
George Elliott 氏 (Univ. Toronto)
The classification of well behaved simple C*-algebras