談話会・数理科学講演会

過去の記録 ~02/06次回の予定今後の予定 02/07~

担当者 加藤晃史、北山貴裕、辻雄(委員長)、三竹大寿
セミナーURL https://www.ms.u-tokyo.ac.jp/seminar/colloquium/index.html

2014年07月25日(金)

16:30-17:30   数理科学研究科棟(駒場) 123号室
旧記録は、上記セミナーURLにあります。
お茶&Coffee&お菓子: 16:00~16:30 (コモンルーム)。

竹内康博 氏 (青山学院大学)
Mathematical modelling of Tumor Immune System Interaction (JAPANESE)
[ 講演概要 ]
We study the dynamical behavior of a tumor-immune system (T-IS) interaction model with two discrete delays,
namely the immune activation delay for effector cells (ECs) and activation delay for Helper T cells (HTCs).
By analyzing the characteristic equations, we establish the stability of two equilibria (tumor-free equilibrium and immune-control equilibrium) and the existence of Hopf bifurcations when two delays are used as the bifurcation parameter.
Our results exhibit that both delays do not affect the stability of tumor-free equilibrium.
However, they are able to destabilize the immune-control equilibrium and cause periodic solutions.
We numerically illustrate how these two delays can change the stability region of the immune-control equilibrium and display the different impacts to the control of tumors.
The numerical simulation results show that the immune activation delay for HTCs can induce heteroclinic cycles to connect the tumor-free equilibrium and immune-control equilibrium.
Furthermore, we observe that the immune activation delay for HTCs can even stabilize the unstable immune-control equilibrium.