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Mathematical Biology Seminar
Seminar information archive ～04/20｜Next seminar｜Future seminars 04/21～
2019/08/01
15:00-16:00 Room #118 (Graduate School of Math. Sci. Bldg.)
Yueping Dong (Central China Normal University)
Mathematical study of the inhibitory role of regulatory T cells in tumor immune response
Yueping Dong (Central China Normal University)
Mathematical study of the inhibitory role of regulatory T cells in tumor immune response
[ Abstract ]
The immune system against tumor is a complex dynamical process showing a dual role. On the one hand, the immune system can activate some immune cells to kill tumor cells, such as cytotoxic T lymphocytes (CTLs) and natural killer cells (NKs), but on the other hand, more evidence shows that some immune cells can help tumor escape, such as regulatory T cells (Tregs). In this talk, we propose a tumor immune interaction model based on Tregs mediated tumor immune escape mechanism. When HTCs stimulation rate by the presence of identified tumor antigens below the critical value, the interior equilibrium P* is always stable in the region of existence. When HTCs stimulation rate higher than the critical value, the Inhibition rate of ECs by Tregs can destabilize P* and cause Hopf bifurcations and produce limit cycle. This model shows that Tregs might play a crucial role in triggering the immune escape of tumor cells. Furthermore, we introduce the adoptive cellular immunotherapy (ACI) and monoclonal immunotherapy as the treatment to boost the immune system to fight against tumors. The numerical results show that ACI can control more tumor cells, while monoclonal immunotherapy can delay the inhibitory effect of Tregs on effector cells (ECs). The results also show that the combination immunotherapy can control tumor cells and reduce the inhibitory effect of Tregs better than single immunotherapy.
The immune system against tumor is a complex dynamical process showing a dual role. On the one hand, the immune system can activate some immune cells to kill tumor cells, such as cytotoxic T lymphocytes (CTLs) and natural killer cells (NKs), but on the other hand, more evidence shows that some immune cells can help tumor escape, such as regulatory T cells (Tregs). In this talk, we propose a tumor immune interaction model based on Tregs mediated tumor immune escape mechanism. When HTCs stimulation rate by the presence of identified tumor antigens below the critical value, the interior equilibrium P* is always stable in the region of existence. When HTCs stimulation rate higher than the critical value, the Inhibition rate of ECs by Tregs can destabilize P* and cause Hopf bifurcations and produce limit cycle. This model shows that Tregs might play a crucial role in triggering the immune escape of tumor cells. Furthermore, we introduce the adoptive cellular immunotherapy (ACI) and monoclonal immunotherapy as the treatment to boost the immune system to fight against tumors. The numerical results show that ACI can control more tumor cells, while monoclonal immunotherapy can delay the inhibitory effect of Tregs on effector cells (ECs). The results also show that the combination immunotherapy can control tumor cells and reduce the inhibitory effect of Tregs better than single immunotherapy.
