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Seminar on Probability and Statistics
Seminar information archive ～04/26｜Next seminar｜Future seminars 04/27～
| Organizer(s) | Nakahiro Yoshida, Teppei Ogihara, Yuta Koike |
|---|
2008/07/10
16:20-17:30 Room #126 (Graduate School of Math. Sci. Bldg.)
吉田 亮 (統計数理研究所)
Bayesian learning of biological pathways on genomic data assimilation
https://www.ms.u-tokyo.ac.jp/~kengok/statseminar/2008/06.html
吉田 亮 (統計数理研究所)
Bayesian learning of biological pathways on genomic data assimilation
[ Abstract ]
States of living cells are controlled by networks of biochemical reactions, referred to as biological pathways, which comprise of, for instance, phosphorylation and binding of protein molecules, gene expressions mediated by transcription factor activities. In systems biology, mathematical modeling and simulation, based on biochemical rate equations, have proved to be a popular approach for unraveling complex machinery of cellular mechanisms. To proceed to simulations, however, it is vital to find the effective values of kinetic rate constants that are difficult to measure directly from in vivo and in vitro experiments. Furthermore, once a set of hypothetical models is given, a proper statistical criterion is needed to test the reliability of the constructed models in terms of predictability and biological robustness. The aim of this research is to present a new statistical technology, called Genomic Data Assimilation, for handling data-driven model construction of biological pathways. The method starts with a knowledge-based pathway modeling with hybrid functional Petri net. It then proceeds to the Bayesian learning of model parameters for which experimental data are available. This process uses time course measurements of biochemical reactants, e.g. gene expression profiles. Another important issue that we consider is statistical evaluation and comparison of the constructed hypothetical models. For this purpose, we developed a new Bayesian information-theoretic measure that assesses the predictability and the biological robustness of models. In this talk, I will detail mathematical aspects of the proposed method, and then, show some statistical issues to be addressed.
[ Reference URL ]States of living cells are controlled by networks of biochemical reactions, referred to as biological pathways, which comprise of, for instance, phosphorylation and binding of protein molecules, gene expressions mediated by transcription factor activities. In systems biology, mathematical modeling and simulation, based on biochemical rate equations, have proved to be a popular approach for unraveling complex machinery of cellular mechanisms. To proceed to simulations, however, it is vital to find the effective values of kinetic rate constants that are difficult to measure directly from in vivo and in vitro experiments. Furthermore, once a set of hypothetical models is given, a proper statistical criterion is needed to test the reliability of the constructed models in terms of predictability and biological robustness. The aim of this research is to present a new statistical technology, called Genomic Data Assimilation, for handling data-driven model construction of biological pathways. The method starts with a knowledge-based pathway modeling with hybrid functional Petri net. It then proceeds to the Bayesian learning of model parameters for which experimental data are available. This process uses time course measurements of biochemical reactants, e.g. gene expression profiles. Another important issue that we consider is statistical evaluation and comparison of the constructed hypothetical models. For this purpose, we developed a new Bayesian information-theoretic measure that assesses the predictability and the biological robustness of models. In this talk, I will detail mathematical aspects of the proposed method, and then, show some statistical issues to be addressed.
https://www.ms.u-tokyo.ac.jp/~kengok/statseminar/2008/06.html
