大 田 佳 宏 (OHTA Yoshihiro)

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特任教授
研究分野 応用数理
研究テーマ
数理生物医学、超離散系シミュレーション
研究概要

超離散系セルオートマトンを用いた遺伝子転写機構の時空間動態シミュレーションの研究、および、Fatgraphなど代数的トポロジーを用いた蛋白質立体構造解析の研究を行っています。

主要論文
  1. Ohta Y, Nishiyama A, Wada Y, Ruan Y, Kodama T, Tsuboi T, Tokihiro T, Ihara S., "Path-preference cellular-automaton model for traffic flow through transit points and its application to the transcription process in human cells", Physical Review E 86, 021918, (2012).
  2. Ohta Y, Kodama T, Ihara S, "Cellular-automaton model of the cooperative dynamics of RNA polymerase II during transcription in human cells", Physical Review E 84, 041922 (2011).
  3. Daigo K*, Kawamura T*, Ohta Y* (* equally), Ihara S, Hamakubo T. et al, "Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors", The Journal of Biological Chemistry, Vol.286, No.1, pp.674-686, Jan. 7, (2011).
  4. Papantonis A, Larkin JD, Wada Y, Ohta Y, Ihara S, Kodama T, Cook PR, "Active RNA Polymerases: Mobile or Immobile Molecular Machines?", PLoS Biology, July (2010), Volume 8, Issue 7, e1000419.
  5. Wada Y* & Ohta Y* (* equally), Kodama T, Cook PR, Ihara S. et al, "A Wave of Nascent Transcription on Activated Human Genes", Proceedings of the National Academy of Sciences, (2009) Oct 27;106( 43) :18357-61,
受賞

The EMBO (European Molecular Biology Organization) Cover Contest 2011 入選

Nature Asia-Pacific HIGHLIGHTS, 23 February 2010.

Science Editors' Choice vol.326, 13 Nov. 2009.