Text only print
Full screen print
Mathematical Biology Seminar
Seminar information archive ～04/19｜Next seminar｜Future seminars 04/20～
2017/12/14
13:00-16:40 Room #126 (Graduate School of Math. Sci. Bldg.)
Xu Yaya 15:40-16:10
Mathematical analysis for HBV model and HBV-HDV coinfection model (ENGLISH)
Xu Yaya 15:40-16:10
Mathematical analysis for HBV model and HBV-HDV coinfection model (ENGLISH)
[ Abstract ]
The hepatitis beta virus (HBV) and hepatitis delta viurs (HDV)
are two common forms of viral hepatitis. However HDV is dependent
on coinfection with HBV since replication of HDV requires the hepati-
tis B surface antigen (HBsAg) which can only been produced by HBV.
Here we start with analyzing HBV only model, the dynamics between
healthy cells, HBV infected cells and free HBV.We show that a postive
equilbrium exsits and it's globally asmptotically stable for R0 > 1, an
infection free equilibrium is globally asymptotically stable for R0 < 1.
Then we introduce HDV to form a coinfection model which contains
three more variables, HDV infected cells, coinfected cells and free HDV.
Additionally, we investigate two coinfection models, one without and
one with treatment by oral drugs which are valid for HBV only. We
consider several durgs with variable eciencies. As a result, compari-
son of model simulations indicate that treatment is necessary to taking
contiously for choric infection.
The hepatitis beta virus (HBV) and hepatitis delta viurs (HDV)
are two common forms of viral hepatitis. However HDV is dependent
on coinfection with HBV since replication of HDV requires the hepati-
tis B surface antigen (HBsAg) which can only been produced by HBV.
Here we start with analyzing HBV only model, the dynamics between
healthy cells, HBV infected cells and free HBV.We show that a postive
equilbrium exsits and it's globally asmptotically stable for R0 > 1, an
infection free equilibrium is globally asymptotically stable for R0 < 1.
Then we introduce HDV to form a coinfection model which contains
three more variables, HDV infected cells, coinfected cells and free HDV.
Additionally, we investigate two coinfection models, one without and
one with treatment by oral drugs which are valid for HBV only. We
consider several durgs with variable eciencies. As a result, compari-
son of model simulations indicate that treatment is necessary to taking
contiously for choric infection.
