談話会・数理科学講演会

過去の記録 ~03/27次回の予定今後の予定 03/28~

担当者 阿部紀行、岩木耕平、河澄響矢(委員長)、小池祐太
セミナーURL https://www.ms.u-tokyo.ac.jp/seminar/colloquium/index.html

2016年10月04日(火)

15:30-16:30   数理科学研究科棟(駒場) 002号室
Odo Diekmann 氏 (Utrecht University)
Waning and boosting : on the dynamics of immune status (ENGLISH)
[ 講演概要 ]
A first aim is to briefly review various mathematical models of infectious disease dynamics that incorporate waning and boosting of immunity. The focus will be on models that are described by delay equations, in particular renewal equations [1]. Concerning within-host dynamics, we limit ourselves to the rather caricatural models of Aron [2] and de Graaf e.a. [3].From a biomedical point of view the main conclusion is that a higher force of infection may lead to less disease,see [4] and the references given there.

[1] O.Diekmann, M.Gyllenberg, J.A.J.Metz, H.R.Thieme, On the formulation and analysis
of general deterministic structured population models. I. Linear theory, J. Math. Biol. (1998) 36 : 349 - 388
[2] J.L. Aron, Dynamics of acquired immunity boosted by exposure to infection, Math. Biosc. (1983) 64 : 249-259
[3] W.F. de Graaf, M.E.E. Kretzschmar, P.M.F. Teunis, O. Diekmann, A two-phase within host model for immune response and its application to seriological profiles of pertussis, Epidemics (2014) 9 : 1-7
[4] A.N. Swart, M. Tomasi, M. Kretzschmar, A.H. Havelaar, O. Diekmann, The protective effect of temporary immunity under imposed infection pressure, Epidemics (2012) 4 : 43-47
[ 参考URL ]
http://www.uu.nl/staff/ODiekmann